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Index absorption extent 1719, 178, 190 rate 2426, 3033 absorption, distribution, metabolism and excretion (ADME) 175 analysis of variance (ANOVA) example 71, 135, 137, 146, 149 statistical model 8083, 219, 227, 229, bioequivalence acceptance range classical 101103, 111112, 134, 197199, 284 modified 101103, 112114 applications 45 average 89, 247249, 253254 replicate designs 258259 definition 23 individual 1112, 207, 230243, 252253, 256, 257258 population 911, 205, 217230, 249252, 255256 Biopharmaceutics Classification System 4 Blue Ribbon Panel 209 caffeine 180181, 184185, 188 carbamazepine 18, 2223, 179, 181, 188 carryover effect estimation of difference nonparametric 66 parametric 59 graphical illustration 58 test for difference nonparametric 65 parametric 60, 81 Cav, see average concentration Cav characteristic, see pharmacokinetic characteristic 232 antihypertensive patch dataset 259278 area under the curve (AUC) composite characteristic excess-AUC 189, 284 extrapolation to infinity 215216, 153 fluctuation 31, 33, 151 partial 2425, 33 single dose 2023, 33, 187 steady state 2627, 33, 187 area under the moment curve (AUMC) 23 AUCt12 191194 auto induction 18 average concentration Easy order forex factory bioavailability definition 2 extent, see absorption, extent rate, see absorption, rate 189194 2223, 132133, 26, 28 Bioequivalence Studies in Drug Development: Methods and Applications D.

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